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All Journal Jurnal Farmasi Udayana Jurnal Ilmiah Medicamento Widya Kesehatan Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Dewi Puspita Apsari
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Physics Public Health

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Journal : Jurnal Farmasi Udayana

 1 
STUDI PENDAHULUAN DERIVATISASI BEBERAPA SENYAWA DENGAN GUGUS AMIN MENGGUNAKAN DANSIL KLORIDA PADA KLT-SPEKTROFOTODENSITOMETER Dewi Puspita Apsari; Ni Putu Linda Laksmiani; I.N.K. Widjaja
Jurnal Farmasi Udayana Vol. 1, No. 1, Tahun 2012
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

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Abstract

Advance derivatization study of several amines with dansyl chloride has been carried out. The aim of this study was to determine influence of molecul structures compound toward dansylation. Derivatization was done by reacting  4000 ng drugs which contain primary or secondary amine group with 100 ng dansyl chloride at a temperature 450 C and pH 9 for a hour. Interference was separated using stationary phase silica G60 and mobile phase  etyl acetat : methanol : ammonia (85:10:5), detection on spectrophotodensytometer ?eks 312 nm mode fluorescence with filter K400. Compounds that have a primary or secondary amine groups can be derivatized using  dansyl chloride though that most affects  of  the reaction is  rigidity of molecul structure. Differences fluorescence intensity between each derivatives influenced by the reactivity amine groups and steric hindrance of the compound.
Co-Authors I K. Putra Juliantara I.N.K. Widjaja Ida Bagus N Maharjana Made Krisna Adi Jaya Muhammad Nanda Aprilianto Ni Luh Desyani Ni Made Krisna Dwiyanti Ni Putu Aryati Suryaningsih Ni Putu Linda Laksmiani Ni Putu Rahayu Martini Ni Putu Widayanti Putra, I Gusti Ngurah Manik Satria Wibawa Putu Eka Arimbawa Siti Sunari, A A Mas Sukmayanti, Ni Luh Putu Ari Sutrisna Putra, I Gusti Putu Agus Ferry Wintariani, Ni Putu